The pituitary gland is a small, pea-sized endocrine gland located at the base of the brain behind the nose. Known as the "master gland," it plays a pivotal role in regulating critical bodily functions and hormones. What does the pituitary gland do? The pituitary is often called the most complex organ in the human body. This tiny gland is responsible for controlling and coordinating activity across the endocrine system by secreting hormones into the bloodstream. Key roles include: